What is 10-OH-THC and what are its properties and effects? How does it differ from 11-OH-THC?
- Origin of 10-OH-THC: hydroxylation and hydrogenation
- How does 10-OH-THC work?
- 10-OH-THC vs. 11-OH-THC: similarities and differences
- Which 10-OH-THC products to include in the product range?
- Conclusion
Origin of 10-OH-THC: hydroxylation and hydrogenation
10-OH-THC, or 10-hydroxy-THC, is a relatively new cannabinoid derivative that is produced by modifying the classic THC (tetrahydrocannabinol) molecule. This modification is carried out through two key chemical processes: hydroxylation and hydrogenation.
These processes alter the original structure of THC and give rise to a compound with unique chemical properties, different from ordinary THC.
|
Feature |
Hydroxylation |
Hydrogenation |
|
Process type |
It occurs naturally during the metabolism of THC in the body |
It does not occur naturally in the body |
|
Use in THC metabolism |
Leads to the formation of 10-OH-THC and other metabolites |
Not part of the natural metabolism of THC |
|
Chemical change |
Addition of a hydroxyl group (-OH) at position 10 in the THC molecule |
Addition of hydrogen (H) atoms to change the structure of THC |
|
Method of execution |
Naturally in the liver or reproducible in the laboratory |
It only takes place under specific laboratory conditions |
|
Laboratory methods |
Enzymatic, chemical, photochemical and other methods | Requires precise conditions such as temperature, pressure and catalysts |
|
Use in scientific/industrial environments |
Often used to mimic the natural hydroxylation of THC in the laboratory | Used for targeted modification of chemical structures, including THC derivatives |
|
Conditions for implementation |
Can take place in the body or in laboratory conditions |
It takes place only under laboratory conditions with specific settings |
In the case of 10-OH-THC produced by hydrogenation and hydroxylation processes in the cannabis industry, it is likely to be a targeted synthesis under laboratory conditions.
How does 10-OH-THC work?
Investigations into the effects of 10-OH-THC are at an early stage and the pharmacological profile of this new cannabinoid and its impact on the human body are still poorly understood.
However, initial studies suggest that 10-OH-THC, like other cannabinoids, affects the endocannabinoid system. This system plays a key role in the regulation of several important physiological functions, such as:
- pain perception
- Immunity
- appetite
- sleep and mood
The endocannabinoid system is primarily made up of two types of receptors: the CB1 and CB2 receptors. CB1 receptors are primarily located in the brain and central nervous system, while CB2 receptors are found primarily in the immune system.
10-OH-THC binds predominantly to CB1 receptors, which can impact cognitive and psychological function. Nevertheless, its psychoactive effects are thought to be minimal and significantly weaker than those of THC, as 10-OH-THC has a lower affinity for these receptors.
Other potential effects of 10-OH-THC can be inferred from its chemical structure and from what we know about the cannabinoids already studied.
Possible benefits of 10-OH-THC include:
- Therapeutic effects: due to 10-OH-THC's ability to interact with cannabinoid receptors in the brain, it is thought that it may have calming effects that could help to relieve stress and anxiety, similar to what has been shown in studies with other cannabinoids. However, these effects could be less pronounced compared to THC.
- Improving sleep quality: According to some users, cannabinoids contribute to easier falling asleep and better sleep quality. For example, in a study published in 2023 in the peer-reviewed journal Exploration of Medicine, 80% of participants reported that cannabis helped them fall asleep, with more than half also reporting deeper sleep. It is possible that 10-OH-THC could have similar but milder effects.
- Anti-inflammatory and analgesic properties: research on cannabinoids in general shows their potential for reducing inflammation and relieving pain. Based on the structural similarity of 10-OH-THC to other known cannabinoids, it is theoretically possible that this compound could exhibit similar effects.
However, it should be emphasized that there are no specific studies yet available to empirically confirm these effects of 10-OH-THC. The above assumptions are mainly based on similarities with other cannabinoids with identical chemical properties.
10-OH-THC vs. 11-OH-THC: similarities and differences
10-OH-THC and 11-OH-THC share some common characteristics - both compounds are not naturally present in the cannabis plant but are produced as metabolites of THC in the human body. And what are the differences between them?
10-OH-THC is a minor metabolite with lower affinity binding to the CB1 receptor, resulting in weaker psychoactive effects as well as less pronounced other potential effects. In contrast, 11-OH-THC is the primary active metabolite, which is characterised by stronger binding to the CB1 receptor and therefore has more intense psychoactive effects and other effects on the organism.
Which 10-OH-THC products to include in the product range?
In our range of products containing 10-OH-THC you will find quality cannabis flowers, prerolls and vape pens. All of these products contain legal levels of THC (below 0.2%) and are suitable for the European market.
Choose from our offer:
- 10-OH-THC enriched flowers: cannabis flowers with 10-OH-THC are a highly sought-after customer destination - offering a smooth and balanced experience with a high 10-OH-THC content (60%) and minimal THC (below 0.2%).
- 10-OH-THC prerolls: pre-packaged joints with 10-OH-THC are a great choice for convenient and quick use. They contain 60% 10-OH-THC and less than 0.2% THC and are ideal for customers looking for a convenient, no-prep solution.
- 10-OH-THC vape pens: Vape pens with 95% concentration of 10-OH-THC and minimal THC content (below 0.2%) are popular with customers for their ease of use (suitable for travel) and quick onset of effects.
For optimal quality preservation, it is necessary to store the flowers and prerolls in a cool and dark place. For this purpose, your customers will appreciate airtight containers.
Conclusion
10-OH-THC is a relatively new cannabinoid that is produced by chemical modification of THC through hydroxylation and hydrogenation. Research into its effects is still at an early stage, but it is thought that it may have similar benefits to other cannabinoids, but with milder effects. This cannabinoid binds primarily to CB1 receptors in the brain, with a weaker psychoactive effect than conventional THC. Preliminary results suggest its potential to improve sleep quality, reduce stress, anxiety, pain and inflammation.
Author: Pavla Skřivánková
Photo: AI
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